CA1323266C - Prophylactic device made of elastomeric material, such as a contraceptive sheath or the like, and process for its manufacture - Google Patents
Prophylactic device made of elastomeric material, such as a contraceptive sheath or the like, and process for its manufactureInfo
- Publication number
- CA1323266C CA1323266C CA000574910A CA574910A CA1323266C CA 1323266 C CA1323266 C CA 1323266C CA 000574910 A CA000574910 A CA 000574910A CA 574910 A CA574910 A CA 574910A CA 1323266 C CA1323266 C CA 1323266C
- Authority
- CA
- Canada
- Prior art keywords
- microcapsules
- layer
- prophylactic device
- elastomer
- pharmacologically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000000069 prophylactic effect Effects 0.000 title claims abstract description 33
- 239000013536 elastomeric material Substances 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims description 19
- 238000004519 manufacturing process Methods 0.000 title claims description 15
- 239000003433 contraceptive agent Substances 0.000 title claims description 12
- 230000002254 contraceptive effect Effects 0.000 title claims description 12
- 239000003094 microcapsule Substances 0.000 claims abstract description 50
- 239000000126 substance Substances 0.000 claims abstract description 3
- 229920001971 elastomer Polymers 0.000 claims description 36
- 239000000806 elastomer Substances 0.000 claims description 31
- 239000013543 active substance Substances 0.000 claims description 28
- 239000004816 latex Substances 0.000 claims description 11
- 229920000126 latex Polymers 0.000 claims description 11
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 6
- 238000004073 vulcanization Methods 0.000 claims description 6
- 238000000151 deposition Methods 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
- GPTXWRGISTZRIO-UHFFFAOYSA-N chlorquinaldol Chemical compound ClC1=CC(Cl)=C(O)C2=NC(C)=CC=C21 GPTXWRGISTZRIO-UHFFFAOYSA-N 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 230000008016 vaporization Effects 0.000 claims description 4
- 238000009834 vaporization Methods 0.000 claims description 4
- WFJIVOKAWHGMBH-UHFFFAOYSA-N 4-hexylbenzene-1,3-diol Chemical compound CCCCCCC1=CC=C(O)C=C1O WFJIVOKAWHGMBH-UHFFFAOYSA-N 0.000 claims description 3
- 230000000840 anti-viral effect Effects 0.000 claims description 3
- 239000003125 aqueous solvent Substances 0.000 claims description 3
- 230000000855 fungicidal effect Effects 0.000 claims description 3
- 229960003258 hexylresorcinol Drugs 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 229920002545 silicone oil Polymers 0.000 claims description 3
- 230000002963 trichomonacidal effect Effects 0.000 claims description 3
- WPRAXAOJIODQJR-UHFFFAOYSA-N 1-(3,4-dimethylphenyl)ethanone Chemical compound CC(=O)C1=CC=C(C)C(C)=C1 WPRAXAOJIODQJR-UHFFFAOYSA-N 0.000 claims description 2
- BITDLWAQPKSXTF-UHFFFAOYSA-M 1-[(3-nitrophenyl)methoxymethyl]pyridin-1-ium;chloride Chemical compound [Cl-].[O-][N+](=O)C1=CC=CC(COC[N+]=2C=CC=CC=2)=C1 BITDLWAQPKSXTF-UHFFFAOYSA-M 0.000 claims description 2
- WEVJJMPVVFNAHZ-UHFFFAOYSA-N 4-amino-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one Chemical compound C1=C(I)C(N)=NC(=O)N1C1OC(CO)C(O)C1 WEVJJMPVVFNAHZ-UHFFFAOYSA-N 0.000 claims description 2
- SODWJACROGQSMM-UHFFFAOYSA-N 5,6,7,8-tetrahydronaphthalen-1-amine Chemical compound C1CCCC2=C1C=CC=C2N SODWJACROGQSMM-UHFFFAOYSA-N 0.000 claims description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 2
- SBKRTALNRRAOJP-BWSIXKJUSA-N N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methylheptanamide (6S)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide sulfuric acid Polymers OS(O)(=O)=O.CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O.CC[C@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O SBKRTALNRRAOJP-BWSIXKJUSA-N 0.000 claims description 2
- 108010093965 Polymyxin B Proteins 0.000 claims description 2
- 239000005708 Sodium hypochlorite Substances 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 claims description 2
- ODFJOVXVLFUVNQ-UHFFFAOYSA-N acetarsol Chemical compound CC(=O)NC1=CC([As](O)(O)=O)=CC=C1O ODFJOVXVLFUVNQ-UHFFFAOYSA-N 0.000 claims description 2
- 229960002364 acetarsol Drugs 0.000 claims description 2
- 229960004150 aciclovir Drugs 0.000 claims description 2
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 claims description 2
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 229960002172 chlorquinaldol Drugs 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims description 2
- 229960003645 econazole nitrate Drugs 0.000 claims description 2
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 claims description 2
- 230000002070 germicidal effect Effects 0.000 claims description 2
- 229960004716 idoxuridine Drugs 0.000 claims description 2
- 150000002730 mercury Chemical class 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- 229960002581 moroxydine hydrochloride Drugs 0.000 claims description 2
- 229960003255 natamycin Drugs 0.000 claims description 2
- 235000010298 natamycin Nutrition 0.000 claims description 2
- 239000004311 natamycin Substances 0.000 claims description 2
- NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 claims description 2
- 229940053050 neomycin sulfate Drugs 0.000 claims description 2
- 230000007935 neutral effect Effects 0.000 claims description 2
- SRQKTCXJCCHINN-NYYWCZLTSA-N nifuratel Chemical compound O=C1OC(CSC)CN1\N=C\C1=CC=C([N+]([O-])=O)O1 SRQKTCXJCCHINN-NYYWCZLTSA-N 0.000 claims description 2
- 229960002136 nifuratel Drugs 0.000 claims description 2
- 229920000847 nonoxynol Polymers 0.000 claims description 2
- 229960000988 nystatin Drugs 0.000 claims description 2
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 claims description 2
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 claims description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims description 2
- 229960003548 polymyxin b sulfate Drugs 0.000 claims description 2
- 239000012286 potassium permanganate Substances 0.000 claims description 2
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims description 2
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 2
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 2
- ZLOXYEZYWCTXHU-UHFFFAOYSA-N tenonitrozole Chemical compound S1C([N+](=O)[O-])=CN=C1NC(=O)C1=CC=CS1 ZLOXYEZYWCTXHU-UHFFFAOYSA-N 0.000 claims description 2
- 229960004480 tenonitrozole Drugs 0.000 claims description 2
- 229960003636 vidarabine Drugs 0.000 claims description 2
- MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229960001950 benzethonium chloride Drugs 0.000 claims 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims 1
- 229960005040 miconazole nitrate Drugs 0.000 claims 1
- 238000000643 oven drying Methods 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 241000700605 Viruses Species 0.000 abstract description 2
- 244000052616 bacterial pathogen Species 0.000 abstract description 2
- 241000233866 Fungi Species 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 238000010008 shearing Methods 0.000 abstract 1
- 238000007654 immersion Methods 0.000 description 4
- 230000001568 sexual effect Effects 0.000 description 4
- 239000000470 constituent Substances 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 2
- 241000725303 Human immunodeficiency virus Species 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 1
- 206010052804 Drug tolerance Diseases 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000019802 Sexually transmitted disease Diseases 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003679 aging effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009172 bursting Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000005354 coacervation Methods 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000026781 habituation Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000008020 pharmaceutical preservative Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000001150 spermicidal effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B25/00—Layered products comprising a layer of natural or synthetic rubber
- B32B25/02—Layered products comprising a layer of natural or synthetic rubber with fibres or particles being present as additives in the layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B42/00—Surgical gloves; Finger-stalls specially adapted for surgery; Devices for handling or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B42/00—Surgical gloves; Finger-stalls specially adapted for surgery; Devices for handling or treatment thereof
- A61B42/10—Surgical gloves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/02—Contraceptive devices; Pessaries; Applicators therefor for use by males
- A61F6/04—Condoms, sheaths or the like, e.g. combined with devices protecting against contagion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/22—Making multilayered or multicoloured articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B25/00—Layered products comprising a layer of natural or synthetic rubber
- B32B25/04—Layered products comprising a layer of natural or synthetic rubber comprising rubber as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B25/042—Layered products comprising a layer of natural or synthetic rubber comprising rubber as the main or only constituent of a layer, which is next to another layer of the same or of a different material of natural rubber or synthetic rubber
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B25/00—Layered products comprising a layer of natural or synthetic rubber
- B32B25/12—Layered products comprising a layer of natural or synthetic rubber comprising natural rubber
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/622—Microcapsules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/08—Coating a former, core or other substrate by spraying or fluidisation, e.g. spraying powder
- B29C41/10—Coating a former, core or other substrate by spraying or fluidisation, e.g. spraying powder by fluidisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2021/00—Use of unspecified rubbers as moulding material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
- B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
- B29K2105/0076—Microcapsules
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S2/00—Apparel
- Y10S2/901—Antibacterial, antitoxin, or clean room
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Medical Informatics (AREA)
- Reproductive Health (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Materials For Medical Uses (AREA)
- Polymerisation Methods In General (AREA)
- Moulding By Coating Moulds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA000616575A CA1332226C (en) | 1987-08-20 | 1992-12-29 | Prophylactic device made of elastomeric material, such as a contraceptive sheath or the like, and process for its manufacture |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8711753 | 1987-08-20 | ||
FR8711753A FR2619503A1 (fr) | 1987-08-20 | 1987-08-20 | Application de microcapsules a la fabrication d'un dispositif prophylactique en materiau elastomere, comme un preservatif ou analogue, et son procede de fabrication |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000616575A Division CA1332226C (en) | 1987-08-20 | 1992-12-29 | Prophylactic device made of elastomeric material, such as a contraceptive sheath or the like, and process for its manufacture |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1323266C true CA1323266C (en) | 1993-10-19 |
Family
ID=9354325
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000574910A Expired - Fee Related CA1323266C (en) | 1987-08-20 | 1988-08-16 | Prophylactic device made of elastomeric material, such as a contraceptive sheath or the like, and process for its manufacture |
CA000616575A Expired - Fee Related CA1332226C (en) | 1987-08-20 | 1992-12-29 | Prophylactic device made of elastomeric material, such as a contraceptive sheath or the like, and process for its manufacture |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000616575A Expired - Fee Related CA1332226C (en) | 1987-08-20 | 1992-12-29 | Prophylactic device made of elastomeric material, such as a contraceptive sheath or the like, and process for its manufacture |
Country Status (17)
Country | Link |
---|---|
US (2) | US4930522A (en]) |
EP (1) | EP0306389B1 (en]) |
JP (1) | JPS6470044A (en]) |
KR (1) | KR970001822B1 (en]) |
CN (1) | CN1012661B (en]) |
AT (1) | ATE77931T1 (en]) |
AU (1) | AU604952B2 (en]) |
BR (1) | BR8804229A (en]) |
CA (2) | CA1323266C (en]) |
DE (2) | DE3872629T2 (en]) |
ES (1) | ES2008647T3 (en]) |
FR (1) | FR2619503A1 (en]) |
GR (2) | GR890300107T1 (en]) |
MA (1) | MA21355A1 (en]) |
MY (1) | MY103343A (en]) |
NZ (1) | NZ225775A (en]) |
TN (1) | TNSN88086A1 (en]) |
Families Citing this family (96)
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US5128168A (en) * | 1987-07-17 | 1992-07-07 | Robin R. T. Shlenker | Method of forming a membrane, especially a latex membrane, having a biocide barrier |
US5130159A (en) * | 1987-07-17 | 1992-07-14 | Shlenker Robin R T | Membranes fashioned from latex and other materials and methods of producing the same |
FR2623712B1 (fr) * | 1987-11-30 | 1991-05-03 | Yakoun Maurice | Element prophylactique anti-infectieux local ou regional a usage medical et veterinaire |
GB8809660D0 (en) * | 1988-04-23 | 1988-05-25 | Smith & Nephew Ass | Gloves |
US5261421A (en) * | 1988-04-23 | 1993-11-16 | Smith & Nephew Plc | Gloves, their manufacture and use |
US5031245B1 (en) * | 1989-04-20 | 1996-09-10 | Smith & Nephew | Gloves their manufacture and use |
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US6175962B1 (en) * | 1988-10-17 | 2001-01-23 | Gary Karlin Michelson | Surgical glove |
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US5483697A (en) * | 1989-05-22 | 1996-01-16 | Board Of Regents The University Of Texas | Multilayer protective coverings with a sealing solution |
US5459879A (en) * | 1989-05-22 | 1995-10-24 | Board Of Regents, The University Of Texas System | Protective coverings |
WO1990014048A1 (en) * | 1989-05-22 | 1990-11-29 | Board Of Regents, The University Of Texas System | Protective coverings |
US5486322A (en) * | 1989-05-22 | 1996-01-23 | Board Of Regents, The University Of Texas System | Production of multilayer productive coverings on conventional dip molding lines |
IT1239030B (it) * | 1989-11-10 | 1993-09-20 | Antonio Magni | Preservativo. |
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AU654162B2 (en) * | 1991-12-19 | 1994-10-27 | Robin R.T. Shlenker | Method of forming a membrane, especially a latex membrane, having a biocide barrier |
CA2058210C (en) * | 1991-12-20 | 1995-02-14 | Clive C. Solomons | Method of forming a membrane, especially a latex membrane, having a biocide barrier |
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IT1272682B (it) * | 1993-09-24 | 1997-06-26 | Pietro Antonino Di | Struttura di profilattico a doppia membrana |
FR2714386B1 (fr) * | 1993-12-23 | 1996-03-08 | Hutchinson | Film d'élastomère, son procédé de préparation et ses applications. |
JP2717497B2 (ja) * | 1993-12-28 | 1998-02-18 | 不二ラテックス株式会社 | 酸性多糖類被覆コンドーム |
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FR2740777B1 (fr) * | 1995-11-02 | 1998-01-02 | Hutchinson | Films d'elastomere contenant au moins une substance chimique active, leur procede de preparation et leurs applications |
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US7709428B2 (en) * | 2005-02-23 | 2010-05-04 | Ansell Healthcare Products Llc | Thickened spreadable warming lubricant |
US8864730B2 (en) * | 2005-04-12 | 2014-10-21 | Rochester Medical Corporation | Silicone rubber male external catheter with absorbent and adhesive |
CA2619700A1 (en) * | 2005-08-17 | 2007-02-22 | Colorado Catheter Company, Inc. | Catheterization assembly |
US7614812B2 (en) * | 2005-09-29 | 2009-11-10 | Kimberly-Clark Worldwide, Inc. | Wiper with encapsulated agent |
US20070144529A1 (en) * | 2005-12-23 | 2007-06-28 | Latrill Bryant | Dimensionally expanding condom |
AT503090B1 (de) * | 2006-01-11 | 2012-06-15 | Semperit Ag Holding | Prophylaxeartikel |
US20070206984A1 (en) * | 2006-03-06 | 2007-09-06 | Redipax, Ltd | Glove for dispensing a substance therefrom to a surface |
US8491552B2 (en) * | 2006-09-25 | 2013-07-23 | Adapta Medical, Inc. | External catheter with antiseptic agent |
US20080142021A1 (en) * | 2006-12-19 | 2008-06-19 | Lamont Van Hook | Condom |
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US8770201B2 (en) * | 2007-10-26 | 2014-07-08 | Glycobiosciences Inc. | Condom with multifunctional coating |
PL2095834T3 (pl) * | 2008-02-21 | 2015-11-30 | Semperit Ag Holding | Artykuł profilaktyczny |
EP2306944A4 (en) * | 2008-07-31 | 2013-07-10 | Ansell Healthcare Prod Llc | CONDOM WITH CAPSULAR COATING |
CN202005873U (zh) * | 2011-02-22 | 2011-10-12 | 爱侣健康科技有限公司 | 具有挤压功能的取精器 |
US9707375B2 (en) | 2011-03-14 | 2017-07-18 | Rochester Medical Corporation, a subsidiary of C. R. Bard, Inc. | Catheter grip and method |
US8491461B1 (en) * | 2011-10-10 | 2013-07-23 | Peter Veslocki | Prophylactic prosthesis assembly |
WO2014059467A1 (en) * | 2012-10-18 | 2014-04-24 | Ansell Limited | Polymeric articles comprising a decoration and method of manufacturing |
US10092728B2 (en) | 2012-11-20 | 2018-10-09 | Rochester Medical Corporation, a subsidiary of C.R. Bard, Inc. | Sheath for securing urinary catheter |
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CN103892956B (zh) * | 2012-12-27 | 2018-10-19 | 浙江相伴乳胶制品有限公司 | 一种具有抗病毒作用的避孕套 |
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CN103340688B (zh) * | 2013-07-16 | 2015-04-08 | 张强 | 一种防针刺外科手套及其制造方法 |
JP6623216B2 (ja) | 2014-08-26 | 2019-12-18 | シー・アール・バード・インコーポレーテッドC R Bard Incorporated | 尿道カテーテル |
CN108201655A (zh) * | 2016-12-16 | 2018-06-26 | 深圳市前海安全入口科技有限公司 | 开放式清洁套及其使用方法 |
CN111107812A (zh) | 2017-09-19 | 2020-05-05 | C·R·巴德股份有限公司 | 导尿管桥接设备、系统及其方法 |
CN111467119A (zh) * | 2020-04-17 | 2020-07-31 | 温州中佣科技有限公司 | 一种可以改善男女性生活的避孕套 |
CN111759575A (zh) * | 2020-07-07 | 2020-10-13 | 汇爆网络科技(杭州)有限公司 | 一种可以检测和保健理疗的避孕套 |
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FR681821A (fr) * | 1929-09-14 | 1930-05-20 | Commande hydraulique des soupapes dans les moteurs à explosions | |
US2586674A (en) * | 1948-11-19 | 1952-02-19 | Lonne Friedrich | Prophylactics |
FR1450673A (fr) * | 1965-07-05 | 1966-06-24 | Comasec | Procédé de fabrication de gants en matière plastique avec support textile |
BE681821A (en]) * | 1966-04-15 | 1966-10-31 | ||
DE1720098A1 (de) * | 1966-08-18 | 1971-06-03 | Eisai Co Ltd | Verfahren zur Herstellung von Praeservativen |
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US4385024A (en) * | 1978-07-31 | 1983-05-24 | Tansill Horace A | Method for making a molded article from a curable material and a curing agent, the curing agent being in a container initially flexible and infrangible which is made frangible |
BE879442A (fr) * | 1978-10-17 | 1980-04-16 | Stolle Res And Dev Corp | Microparticules contenant des agents therapeutiques ou medicinaux et leur application comme contraceptif |
US4332243A (en) * | 1980-04-04 | 1982-06-01 | Morton Gutnick | Devices and methods for the prevention of transmission of venereal disease and non-gonococcal genital infections |
ZA827582B (en) * | 1981-11-06 | 1983-08-31 | Ansell Inc | Spermicidal condom |
US4463156A (en) * | 1982-03-15 | 1984-07-31 | Warner-Lambert Co., Inc. | Polyurethane elastomer and an improved hypoallergenic polyurethane flexible glove prepared therefrom |
AU567155B2 (en) * | 1983-04-15 | 1987-11-12 | Damon Biotech Inc. | Capsules for releasing core material at constant rate |
US4771482A (en) * | 1987-07-17 | 1988-09-20 | Shlenker Robin R T | Glove for inhibiting the spread of contagious diseases and method of using the same |
US4853978A (en) * | 1987-07-24 | 1989-08-08 | Surgikos, Inc. | Antimicrobial medical glove |
-
1987
- 1987-08-20 FR FR8711753A patent/FR2619503A1/fr not_active Withdrawn
-
1988
- 1988-08-08 AU AU20466/88A patent/AU604952B2/en not_active Ceased
- 1988-08-10 NZ NZ225775A patent/NZ225775A/xx unknown
- 1988-08-10 MY MYPI88000915A patent/MY103343A/en unknown
- 1988-08-15 US US07/232,336 patent/US4930522A/en not_active Expired - Fee Related
- 1988-08-16 CA CA000574910A patent/CA1323266C/en not_active Expired - Fee Related
- 1988-08-17 ES ES198888402116T patent/ES2008647T3/es not_active Expired - Lifetime
- 1988-08-17 EP EP88402116A patent/EP0306389B1/fr not_active Expired - Lifetime
- 1988-08-17 AT AT88402116T patent/ATE77931T1/de not_active IP Right Cessation
- 1988-08-17 MA MA21598A patent/MA21355A1/fr unknown
- 1988-08-17 DE DE8888402116T patent/DE3872629T2/de not_active Expired - Lifetime
- 1988-08-17 DE DE198888402116T patent/DE306389T1/de active Pending
- 1988-08-18 KR KR1019880010476A patent/KR970001822B1/ko not_active Expired - Fee Related
- 1988-08-18 TN TNTNSN88086A patent/TNSN88086A1/fr unknown
- 1988-08-19 BR BR8804229A patent/BR8804229A/pt not_active IP Right Cessation
- 1988-08-19 JP JP63207201A patent/JPS6470044A/ja active Granted
- 1988-08-19 CN CN88106110A patent/CN1012661B/zh not_active Expired
-
1989
- 1989-10-31 GR GR89300107T patent/GR890300107T1/el unknown
-
1990
- 1990-03-28 US US07/500,377 patent/US5024852A/en not_active Expired - Fee Related
-
1992
- 1992-09-03 GR GR920401933T patent/GR3005607T3/el unknown
- 1992-12-29 CA CA000616575A patent/CA1332226C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2008647A4 (es) | 1989-08-01 |
US5024852A (en) | 1991-06-18 |
KR970001822B1 (ko) | 1997-02-17 |
ES2008647T3 (es) | 1993-04-01 |
DE3872629T2 (de) | 1992-12-03 |
ATE77931T1 (de) | 1992-07-15 |
BR8804229A (pt) | 1989-03-14 |
CA1332226C (en) | 1994-10-04 |
CN1031648A (zh) | 1989-03-15 |
AU604952B2 (en) | 1991-01-03 |
MA21355A1 (fr) | 1989-04-01 |
US4930522A (en) | 1990-06-05 |
FR2619503A1 (fr) | 1989-02-24 |
GR3005607T3 (en]) | 1993-06-07 |
AU2046688A (en) | 1989-02-23 |
EP0306389B1 (fr) | 1992-07-08 |
DE3872629D1 (de) | 1992-08-13 |
CN1012661B (zh) | 1991-05-29 |
KR890003345A (ko) | 1989-04-14 |
JPS6470044A (en) | 1989-03-15 |
TNSN88086A1 (fr) | 1990-07-10 |
JPH0440023B2 (en]) | 1992-07-01 |
DE306389T1 (de) | 1989-09-14 |
MY103343A (en) | 1993-05-29 |
GR890300107T1 (en) | 1989-10-31 |
EP0306389A1 (fr) | 1989-03-08 |
NZ225775A (en) | 1990-07-26 |
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